The protective effect of infliximab against carbon tetrachloride-induced acute lung injury

Authors

  • Aysel Kurt Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey
  • Erkan Cure Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey
  • Gokhan Pusuroglu Recep Tayyip Erdogan University, School of Medicine, Department of Internal Medicine, Rize, Turkey
  • Hasan Turut Recep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey
  • Ibrahim Sehitoglu Recep Tayyip Erdogan University, School of Medicine, Department of Pathology, Rize, Turkey
  • Levent Tumkaya Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey
  • Medine Cumhur Cure Recep Tayyip Erdogan University, School of Medicine, Department of Biochemistry, Rize, Turkey
  • Suleyman Yuce Department of Internal Medicine, Ordu Kumru State Hospital, Ordu, Turkey
  • Yildiray Kalkan Recep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey
Abstract:

Objective(s): Carbon tetrachloride (CCl4) causes pulmonary toxicity. Infliximab (Ib) is a potent inhibitor of tumor necrosis factor-alpha (TNF-α). We aimed to investigate whether Ib has a protective effect on CCl4 induced lung injury. Materials and Methods:Rats were divided into control, CCl4, and CCl4+Ib groups. A single dose of 2 ml/kg CCI4 was administered to CCI4 group and a single dose of 7 mg/kg Ib was given to CCl4+Ib group 24 hr before applying CCI4. Results:TNF-α, malondialdehyde (MDA), nitric oxide (NO) and caspase-3 levels of the CCl4 group were markedly higher than both the control and CCl4+Ib groups. The CCI4+Ib group had lower histopathological injury than the CCl4 group. Conclusion:Ib as a strong TNF-α blocker decreases the production of proinflammatory cytokines, MDA, and oxidative stress leading to a protective effect against CCl4 induced lung tissue injury.

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Journal title

volume 19  issue 6

pages  685- 691

publication date 2016-06-01

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